| NIMERAL-T Tablets Rationale of Combination
No single molecule available in the market is capable of
termination of the pain – spasm – pain vicious cycle. Drugs like Nimesulide a
potent COX II inhibitor and Tizanidine, a centrally acting muscle relaxant provide a
convenient and effective combination to combat pain as well as to relax the muscle spasm.
Tizanidine is a short acting drug for acute and intermittent management for increased
muscle tone associated with pain. As both the drugs have similar pharmacokinetic profile,
together they offer excellent efficacy to terminate pain – spasm – pain cycle.
Nimesulide Clinical Pharmacology
The advantages of Nimesulide are – It is well
tolerated gastrointestinally. May be administered to patients with bronchial asthma and in
aspirin sensitive individuals. Nimesulide reduces superoxide generation by neutrophils.
Nimesulide Clinical Pharmacology
It is an imidazole derivative that exhibits central
skeletal muscle relaxant property. It prevents muscular contraction by inhibiting the
motor response acting via presynaptic A-2 receptors.
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